People that are skinny vs someone bigger, more likely to break bones or feel pain?

[Zero]

Of course.

However, most of them are illegal. All of them are illegal to use on an unsuspecting target.

That said, the drug C2H6O is still technically legal in most cases, is most often used consensually, and is a very very common "anti-rejection drug to work on [insert female here]." I'd wager, in fact, it's the most common drug for these purposes.

Peace favor your sword,
Kirk

Ha! Thanks, although I kinda wished I'd never asked now!! : ) I think she was an antidote to your C2H cocktail...it's called mace