The nose through to the brain, I was told about this technique by a teacher a while back, when we where learning about, anatomical weak points, pressure points, nerve attacks etc, it was stated that a palm strike at a 45 degree angle upwards would result in the brain injury, I do not know if it is true, never tried it, never wanted to try it, and never heard of it happening, however, in these classes we where told about the pressure point M HN 5, which is on the eyebrow about 1 inch above the pupil, ( you can find it by running the finger along the eye brow until you find a dip/recess), you will not find this point on the usual run of the mill meridian maps. A similar strike to the one mentioned will result in a knock out on most people, tried it several times, and it works, striking this point at a different angle has the possible effect of eye damage and or damage to the optic nerve and possible death, now I have not tried or wanted to try this other angle. Other things this teacher taught where true, and I have no reason to doubt it's true, but sometimes striking the right place, in the right way, is the only way to get the right result.