I agree it is person specific.
When I was competing, amino acids were a big part of my nutrition plan. Ate them like candy it seemed.
Our son is a very fit, very active late 20-year old. Two years ago totally out of the blue he woke up very swollen. Long story short, he had/has FSGS. For a while it was a roller coaster of looking like an anorexic meth head to rather overweight. Things finally worked themselves out. He is on no medication and just watches what he eats.
On a side note, while he was in the hospital he got c-diff. He said that was rougher than the kidney issues.