I'm pretty fat, though I am struggling to lose the weight. And of course, as a newbie to MA, I'm not claiming to have any real insight, other than that of being a fat guy who spars. Couple thoughts.
First, my legs are STRONG. They're like oak trees. You won't do much with your wiry strong legs kicking at my monsters. Oh, it's going to hurt, sure, but you're not likely to get through that muscle to do any real damage. Those legs have been carrying our gigantic butts around for a long time, lots of exercise. My calves ain't calves, they's the whole bull.
Second, our kicks are liable to be low and slow but powerful. Easy to evade, but not easy to trap - unless you're significantly shorter than we are. However, watch out for sweeps - we have so much mass going for us, we can take you off what you think is a stable position if we get a good angle on you.
Third, the key to taking down a fat man is balance. We have a much harder time centering ourselves, and we overbalance easily. Recovery is slow from an off-balance position - that's minor muscle groups trying to stabilize a top-heavy load that they're not used to trying to control quickly. Trap a punch and pull it to your waist and step back, we go over towards you. Then you can take the legs right out, or just pull sharply and let us fall.
And for those who think the belly is a good target - you might want to reconsider that one. I have a huge gut - and it is rock hard. I do situps and pushups until I want to die. I don't have the six-pack, I have the entire keg. My fat is literally UNDER the muscle layer. You're not likely to get much from me with a nukite to the gut except jammed fingers.
A couple more targets on a fat man - the flab grab-and-twist under the arms, and the nerve strikes under the armpits - fat there does not do much to protect those areas from a nerve stike (trust me on this). The spare tire flab twist can also be effective if the guy has a significant one.