As someone who has been a stand up fighter for almost 2 decades, with 16 years being spent in Kenpo I was curious how I would fare against the grapplers, other then the ones I had faced already. I took some BJJ classes to test myself and fell in love with the SPORT aspect of BJJ.
Please note that SPORT is capitalized for a reason. I feel that regardless of who is coming at me, the weapons I was taught in kenpo are more then adequate to deal with them. Finger strikes, soft tissue attacks, pinches small joint manipulation, etc.
Now I have been training for going on 4 years and am a purple belt in BJJ, and I advocate it to any stand up artist, but I think the vast majority of grapplers, even the higher level grapplers are simply studying a sport version of the art, they train constantly for the RULES, and find a hard time compensating for the lack of them in a street fight. That being said a grappler intent on hurting you can probably move past a fairly major eye injury or groin shot, or throat shot or broken finger and try to apply a submission, or ground and pound. Which is a big reason I advocate training on the ground for any stand up artist. I personally feel that a combination of environmental awareness, a good sprawl, and training in the ground game will give a stand up fighter all the tools he needs to avoid going to the ground to begin with, and the dirty self defense skills will help get off the ground if it happens.