Cure for depression?

[Gyakuto]

Researchers found that a single, carefully administered dose of psilocybin can produce rapid and sustained improvements in individuals with severe treatment-resistant depression, offering new hope when traditional therapies have failed.

Single-Dose Psilocybin for Depression With Severe Treatment Resistance: An Open-Label Trial - PubMed

This open-label study suggests efficacy and safety of psilocybin in severe TRD and supports further study of psychedelics in this population, including consideration of PTSD interaction effects.

pubmed.ncbi.nlm.nih.gov

The participants had tried at least five prior treatments without any improvement. Then, they received one 25-milligram dose of psilocybin alongside psychological support. Just three weeks after treatment, the changes were hard to deny. Nearly 70 percent of participants experienced a signification reduction in their symptoms, and 42 percent achieved complete remission.

The results indicated that the benefits lasted up to 3 months, suggesting one treatment could have long-term benefits. The treatment was well-tolerated with no serious adverse effects reported, underscoring its potential as a safe alternative for people with limited options.

 

[HighKick]

Researchers found that a single, carefully administered dose of psilocybin can produce rapid and sustained improvements in individuals with severe treatment-resistant depression, offering new hope when traditional therapies have failed.

Single-Dose Psilocybin for Depression With Severe Treatment Resistance: An Open-Label Trial - PubMed

This open-label study suggests efficacy and safety of psilocybin in severe TRD and supports further study of psychedelics in this population, including consideration of PTSD interaction effects.

pubmed.ncbi.nlm.nih.gov

The participants had tried at least five prior treatments without any improvement. Then, they received one 25-milligram dose of psilocybin alongside psychological support. Just three weeks after treatment, the changes were hard to deny. Nearly 70 percent of participants experienced a signification reduction in their symptoms, and 42 percent achieved complete remission.

The results indicated that the benefits lasted up to 3 months, suggesting one treatment could have long-term benefits. The treatment was well-tolerated with no serious adverse effects reported, underscoring its potential as a safe alternative for people with limited options.

So, you will promote a hallucinogenic but worry about ground wheat?

 

[Gyakuto]

So, you will promote a hallucinogenic but worry about ground wheat?

Am I promoting it or informing those interested in such things?

 

[HighKick]

Am I promoting it or informing those interested in such things?

Fair enough, but hard pass for me.
I am open to a homeopathic approach and do use some but have no desire to alter my mind or thinking.

 

[Gyakuto]

I am open to a homeopathic approach and do use some

Homeopathy is total bunkum…it’s a scam.

https://www.youtube.com/results?search_query=homeopathic+a+and+e

but have no desire to alter my mind or thinking.

You might not say that if you had intractable depression.

 

[Fungus]

Single dose? Wow that is interesting indeed.

Also interesting as 5-HT2A activation suppresses the other serotonin receptors, such as 5-HT1A with is the main normal target in depression, which is why 5-HT2A antagonists enhance SSRI drugs in depression. But I suppose this also indicates how heterogenous depressions are as well?! After all this was for treatment resistance depression, which is indicative of different mechanisms.

I wonder if the "direction" of neuroplastic changes, is effectively in the right direction in this case? Is it coincidental, or does this appear sponteanously as plasticity increases because of the depression itself - self healing??

 

[Prince_Alarming]

Mushroom stroganoff, anyone?