Tony, can you clarify what you mean by in-depth understanding of self-defense issues and applications?
Also, I should point out that I'm NOT looking to offer any 'how to beat the crap out of an attacker' type deal.
Offhand, I'd include things like:
Lifestyle habits to avoid dangerous situations
Recognizing different sorts of dangerous situations and understanding how to exit them or maneuver safely through them
Knowing how to carry oneself so as to be an unappealing target for predators
Learning how to read people so as to recognize dangerous individuals, understand them and what sets them off
Controlling ones ego and temper so as not to provoke or escalate bad situations
Verbal de-escalation skills
Escape and evasion skills
Understanding legalities regarding use of force
Knowing how to behave in the aftermath of an attack, including dealing with emotional issues and talking to law enforcement
I'm sure there are more considerations that I'm not thinking of at the moment, but you get the idea. I'm leaving aside aspects such as actual physical fighting technique and mental/physical conditioning, since those should ideally be included in your martial arts curriculum. (If your martial art curriculum is primarily geared towards sport or cultural tradition, then you should add appropriate physical techniques for real world violence to the list.)
When I say "in depth" I mean that you know more about the topics listed above than you could conveniently convey in an hour or two of lecture. when I say "know" I mean that your information is based on experience or research from reputable experts, not pulled from random internet sources or your imagination.
I've picked up enough self-defense knowledge over the years through personal experience, seminars, books, and conversations with experts that I feel comfortable keeping myself safe and tossing out the occasional useful tip to students or friends. I don't know that I would count myself as sufficiently expert to run an ongoing self-defense class for women, especially since the dangers a typical woman faces are somewhat different from what I (a 6'4" man) have to deal with.