From the Sayoc Website...
The Sayoc Kali system of knife work includes methods of targeting different vital points of the body. These targeting systems are known as vital templates. This is in contrast to systems that commonly just present a system of angles by which to deliver knife strikes which may or may not have an equivalent degree of effectiveness. We apply our left hand vital templates that were developed to counter the right hand vital templates. The right hand vital templates are designed to counter reflexive and conditioned responses. The left hand vital templates were designed to react to correct responses.
In other words, Sayoc Kali is very feeder based. Meaning you present an attack and see what response you get, if you get a "bad hand" type of response, continuing the flow of the vital template will allow your blade to seek the correct path. If you get a correct response. the left hand template (holding a blade) comes into play. The left and right are done seperate and together in practice.
Think of it as more scientific approach, but similar to a boxing combination. Punch high, he covers his head, so hit low.