I've been there several times. I know you'll find these things during your research but - if you rent a car, they drive on the left in South Africa, if you've never done that before, the first few days are really confusing, especially turning. A lot of the car rentals are manual transmission, if you want an automatic you need to request it. And you need a locking gas cap. Any picture driving license is valid, so you're all set.
You need a cell phone. Find out if yours will work there. But if you use it a lot the international rates will cost you a bootload. (seriously) Depending on how long you're staying, might be better to get one there, and their service. I think the emergency number is 10111.
If you plan on traveling by bus - bad guys always work the bus depots, always, so be careful. If you're in the cities at night, stay away from the business or night districts. If you're marked as a tourist they'll eat you alive. Just don't go to those places at night.
If you are out and about, "in the woods" (more like dusty scrub) there's more to worry about than coyotes, wolves or bears. Always remember YOU ARE IN AFRICA. Besides the animals, they have seriously nasty snakes. Black Mambas, Puff Adders, Boomslangs in the trees and Cobras, all kinds of Cobras, and God knows what else. I'm quite sure you'll see them (at least I hope you see them)
It's also the "murder by stabbing capital of the world", so behave yourself.
Thanks for the advice. Anyway, the company that I would be signing up with for the hunt, they provide transportation from the airport to the lodge and back. Every day you rise early in the morning and hunt all day and at night you stay at the lodge. I don't know what they do for communications so I will look into getting a cell phone there, or talking to my provider about international service. I will also ask the company about that. I've got a friend who is from South Africa and he says I should get along just fine speaking English as its a commonly spoken language there. Aside from that I am also looking for a partner for the hunt as you can save money if two people go.